TAGLN — Transgelin
TAGLN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAGLN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Myofibroblast Contractile Cytoskeletal | ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, LPP, MSRB3 +7 more | View in SCUBA |
| Monocytes | Macrophage Differentiation Developmental | C7orf50, CABP4, FCGR3B, FMNL2, IL3RA, MS4A4A, MSR1, PPM1N +3 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | ACTA2, CSRP1, FLNA, MYL9, MYLK, NEXN, PPP1R14A, S100A4 +2 more | View in SCUBA |
| Smooth muscle cells | SMC contractile apparatus Contractility | ACTA2, ACTB, CALD1, CAV1, DSTN, MYL6, MYL9, PPP1R14A +2 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686P11128, SM22, SMCC, TAGLN1, WS3-10 |
|---|---|
| Chromosome | 11: 117199370-117207464 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, Muscle protein |
Function
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.