NEXN — Nexilin F-actin binding protein
NEXN belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NEXN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Myofibroblast Contractile Cytoskeletal | ACTA2, CCDC107, CFL2, CSRP1, FLNA, ILK, LPP, MSRB3 +7 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | ACTA2, CSRP1, FLNA, MYL9, MYLK, PPP1R14A, S100A4, TAGLN +2 more | View in SCUBA |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | NELIN, nexilin |
|---|---|
| Chromosome | 1: 77888513-77943895 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.