TBL1XR1 — TBL1X/Y related 1

TBL1XR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TBL1XR1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Actomyosin signaling migration & adhesion	ACIN1, CYBC1, EIF4G3, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH +8 more	View in SCUBA
Gamma-delta T cells	Transcriptional Repressor Complex DNA/chromatin regulation	BAG1, CAB39, CLEC2B, EBP, FBXO31, GFI1, MAN1A1, MAP2K1 +14 more
Innate lymphoid cells	Golgi RNA Processing RNA processing & translation	ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 more	View in SCUBA
Macrophages	Sphingolipid Membrane Homeostasis Lipid metabolism	ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8 +12 more	View in SCUBA

About the gene

Synonyms	C21, DC42, FLJ12894, IRA1, TBLR1
Chromosome	3: 177019340-177228000
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Activator, Chromatin regulator, Repressor
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.