M6PR — Mannose-6-phosphate receptor, cation dependent
M6PR belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
M6PR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | ER/vesicle trafficking Protein processing & ER | ATP6V0B, CD99, DIAPH1, HCST, MTDH, MTPN, REEP5, SCPEP1 +1 more | View in SCUBA |
| CD4⁺ T cells | Cell motility/adhesion migration & adhesion | ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B +14 more | View in SCUBA |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CALR, CSTB, CTNND1, HSP90B1, LPAR6, MRPS6, PDIA6, PRDX1 +3 more | View in SCUBA |
About the gene
| Synonyms | CD-M6PR, CD-MPR |
|---|---|
| Chromosome | 12: 8940361-8949761 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Transport |
Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.