BCR Ras signaling
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by signaling adaptors and regulators of lymphocyte activation: PAG1 (Cbp, a Src-family kinase regulator at the immunological synapse), SCIMP (SLP65/SLP76-interacting membrane protein in B cells/APCs), HSH2D (hematopoietic SH2 domain adaptor), RASGRP3 and RASGRP1 (Ras guanine nucleotide exchange factors downstream of antigen receptor signaling), and TIAM2. TOX and HOPX are transcriptional regulators associated with lymphocyte differentiation/exhaustion states. ITGAM and CCL5 indicate an activated/effector immune phenotype. The collection of antigen-receptor proximal signaling adaptors (SCIMP, RASGRP3, RASGRP1, PAG1, HSH2D) points to BCR-coupled signaling. The positive association with inflammation (delta_inflammation_UC sig.) supports an activation-related program. Uniform expression, no contaminating lineage dominance. Coherence is strong, fitting a single signaling program centered on antigen-receptor/Ras activation.
Genes
ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM, MCOLN2, PAG1, RABGAP1L, RASGRP1, RASGRP3, SCIMP, SHISA8, SP140, SYT1, TIAM2, TOX, TSPO, ZBTB38
Most correlated modules
- B cell activation · correlation 0.88
- ER/vesicle trafficking · correlation 0.79
- Actin cytoskeleton remodeling · correlation 0.78
- B-cell activation signaling · correlation 0.71
- MHC-II antigen presentation · correlation 0.65
- mRNA splicing · correlation 0.63
- Activated B cell · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.