NSD1 — Nuclear receptor binding SET domain protein 1
NSD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | JAK-STAT Signaling Immune regulation | ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, JAK3, MBNL1 +7 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4 +18 more | |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ARHGAP26, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3 +21 more |
About the gene
| Synonyms | ARA267, FLJ22263, KMT3B, STO |
|---|---|
| Chromosome | 5: 177131830-177300213 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator, Methyltransferase, Repressor, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.