RNA processing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Dominated by RNA processing/ribosome biogenesis and splicing factors: NAF1 (H/ACA snoRNP, telomerase RNA biogenesis), TAF1D (rRNA processing), HNRNPAB and HNRNPDL (hnRNP splicing/mRNA stability), SAP18 (spliceosome/ASAP complex), AARSD1 (aminoacyl-tRNA related). Additional genes include FRAT1 (Wnt), CALM2, IRF2BPL, CHMP1B (ESCRT), IL27RA (cytokine receptor). The hub and core members are predominantly RNA/ribosome biogenesis factors, supporting an RNA processing identity. Uniform expression, no contamination.
Genes
AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB, HNRNPDL, IL27RA, IRF2BPL, NAF1, NTMT1, SAP18, SPINT2, TAF1D
Most correlated modules
- Mixed Metabolic Ambient · correlation 0.77
- mRNA Splicing Processing · correlation 0.64
- Activated Effector ISG · correlation 0.63
- mRNA Splicing Factors · correlation 0.62
- Hypoxia metabolic stress · correlation 0.48
- Immediate early activation · correlation 0.48
- Integrated Stress Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.