Hypoxia metabolic stress
Gene co-expression module in CD4⁺ T cells
| Category | Stress |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include BNIP3 (hypoxia-induced mitophagy), ARG2, GSTM3 (oxidative stress), ID3, AXIN2 (Wnt target), STMN1, MARCKSL1. The mix of BNIP3 and ARG2 points to a hypoxia/metabolic stress response, with some cytoskeletal (STMN1, MARCKSL1) and Wnt (AXIN2, ID3, KLF5) elements. The dominant coherent theme is a hypoxia/metabolic stress program.
Genes
ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3, ID3, KCTD12, KLF5, MARCKSL1, NKX3-1, SLC16A10, SLC25A4, STMN1, TAF4B, TENT5A, TLE4, TOB1, VASN, ZNF563
Most correlated modules
- Naive T cell · correlation 0.76
- Integrated Stress Response · correlation 0.71
- Naive T cell · correlation 0.71
- Immediate early activation · correlation 0.70
- Pol II Transcription Regulation · correlation 0.68
- Naive T quiescence · correlation 0.66
- T cell quiescence · correlation 0.61
- T cell signaling · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.