IL10/cytokine signaling
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 13 genes have a known function matching the annotation |
Why this annotation
Top hubs include IL10RA (IL-10 receptor, immune regulation), IL7 (cytokine), TNFRSF13B (TACI, B-cell help/cytokine receptor), and various transport/scaffold genes. IL10RA and TNFRSF13B point to an immunoregulatory/cytokine receptor program. The inflammation-associated upregulation and IL10RA hub status support an immune regulation label, with IL7 reflecting homeostatic cytokine signaling. The module is otherwise diffuse but anchored on IL10RA.
Genes
CASK, CCDC141, FOXN3, IL10RA, IL7, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B, TOR1AIP2, TTN, UGP2, VPS54
Most correlated modules
- Regulatory T cell · correlation 0.92
- Activated Treg · correlation 0.84
- MAPK feedback signaling · correlation 0.83
- LAYN+ tissue Treg · correlation 0.79
- TCR signaling activation · correlation 0.78
- NF-kB feedback · correlation 0.75
- Chromatin transcription regulation · correlation 0.67
- Inflammatory effector · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.