ITGB2 — Integrin subunit beta 2

ITGB2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ITGB2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B-cell activation B cell maturation	ADAM19, ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, ELK3 +15 more	View in SCUBA
CD4⁺ T cells	Leukocyte adhesion signaling migration & adhesion	ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more	View in SCUBA
CD8⁺ T cells	Effector-Memory CD8 T cell maturation	CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R +8 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Program cytotoxicity	APMAP, C16orf54, CST7, CTSW, EHD1, HLA-A, HLA-B, HLA-C +8 more
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more	View in SCUBA
Macrophages	Oxidative Metabolic Program Mitochondrial & OxPhos	ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more	View in SCUBA
Mucosal-associated invariant T cell	Mature Effector MAIT T cell maturation	ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6 +7 more
Neutrophils	Actin Cytoskeleton Dynamics Cytoskeletal	ACTB, ACTG1, ARPC5, CFL1, CORO1A, MYL6, PFN1, RGL4 +6 more

About the gene

Synonyms	CD18, LFA-1, MAC-1, MFI7
Chromosome	21: 44885953-44931989
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Integrin, Receptor
Biological process	Cell adhesion, Phagocytosis

Function

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3- mediated activation of TNF primed neutrophils.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.