RAB31 — RAB31, member RAS oncogene family
RAB31 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB31's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1 +6 more | View in SCUBA |
| Endothelial | Housekeeping Metabolic Housekeeping | ANXA5, ATP5MC3, CCT5, COX6B1, CTSL, DCTPP1, ERH, GSTO1 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CCR7, CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM +4 more | |
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1 +27 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, HEPH +6 more | View in SCUBA |
About the gene
| Synonyms | Rab22B |
|---|---|
| Chromosome | 18: 9708275-9862551 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans- Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.