RRM1 — Ribonucleotide reductase catalytic subunit M1
RRM1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RRM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle G1/S Cell cycle | CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, HMGN2, MND1 +8 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF +5 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CENPM, CLSPN, DNAJC9, FANCI, LIG1, PKMYT1 | View in SCUBA |
| Hematopoietic progenitor cells | S-phase Progression Cell cycle | ATAD2, ATAD5, BRCA2, DNMT1, FANCI, LMNB1, SMC2, TMPO +1 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Chromosome | 11: 4094707-4138932 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Oxidoreductase |
| Biological process | Deoxyribonucleotide synthesis |
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.