TCF25 — Transcription factor 25

TCF25 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TCF25's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Chromatin regulation DNA/chromatin regulation	ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A +12 more	View in SCUBA
Gamma-delta T cells	Innate Stress Signaling Inflammation	AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2 +23 more
Goblet cells	Pyroptosis Stress Response Stress	ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD +6 more	View in SCUBA
Innate lymphoid cells	mTOR Metabolic Stress Stress	ADPGK, AKR1A1, ATP5IF1, BAX, CPNE1, GLO1, GSTO1, HNRNPR +9 more	View in SCUBA
Macrophages	mRNA Splicing Processing Housekeeping	ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more	View in SCUBA

About the gene

Synonyms	KIAA1049, Nulp1
Chromosome	16: 89873570-89913627
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Function

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1. May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.