TNFAIP8 — TNF alpha induced protein 8
TNFAIP8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFAIP8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20 +8 more | View in SCUBA |
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5 +13 more | |
| Innate lymphoid cells | TRiC Chaperonin Folding Protein processing & ER | ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2 +9 more | View in SCUBA |
| Monocytes | NF-κB Counter-regulation Inflammatory | ABL2, C15orf48, CD274, GPR84, IL1RN, RHOH, TNIP3 | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GOPC, GRAP2, IRF2, LPAR5, MTAP, PDCD10, SENP7 +3 more |
About the gene
| Synonyms | GG2-1, MDC-3.13, SCC-S2 |
|---|---|
| Chromosome | 5: 119268692-119399688 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.