METTL5 — Methyltransferase 5, N6-adenosine
METTL5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
METTL5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Housekeeping Mitochondrial & OxPhos | ARL2, BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3 +13 more | |
| Innate lymphoid cells | TRiC Chaperonin Folding Protein processing & ER | ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more | View in SCUBA |
About the gene
| Synonyms | HSPC133 |
|---|---|
| Chromosome | 2: 169810081-169824931 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.