TMEM38B — Transmembrane protein 38B
TMEM38B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM38B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Autophagy Regulation Immune regulation | CLIC2, GABARAPL1, LGMN, NFKBIB, OSER1, PRRG4, RELB, RNF114 +3 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3 +10 more | View in SCUBA |
About the gene
| Synonyms | bA219P18.1, C9orf87, D4Ertd89e, FLJ10493, TRIC-B |
|---|---|
| Chromosome | 9: 105694541-105776629 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Potassium channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Activated by increased cytosolic Ca(2+) levels (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.