LIF — LIF interleukin 6 family cytokine
LIF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Lymphatic endothelial | AhR mRNA Regulation RNA processing & translation | CYP1B1, DHRS3, ESAM, HNRNPDL, HNRNPH1, SDC4, TIPARP, TPBG +3 more | View in SCUBA |
About the gene
| Synonyms | CDF, DIA, HILDA |
|---|---|
| Chromosome | 22: 30240453-30246759 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor |
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.