RNF19A — Ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF19A belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF19A's module in each cell type
About the gene
| Synonyms | DKFZp566B1346, dorfin, RNF19 |
|---|---|
| Chromosome | 8: 100257060-100336218 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.