TNFSF9 — TNF superfamily member 9
TNFSF9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFSF9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activation/Migration BCR/AP1/NFKb pathway | AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6 +11 more | View in SCUBA |
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more | View in SCUBA |
| Endothelial | NF-κB Activation Inflammation | C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, NFKBID, PMAIP1 +5 more | View in SCUBA |
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more | |
| Macrophages | Early response genes Inflammatory | ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation T cell maturation | BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more |
About the gene
| Synonyms | 4-1BB-L, 4-1BBL, CD137L |
|---|---|
| Chromosome | 19: 6531026-6535924 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Cytokine |
Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation- induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.