Inflammatory Stress Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
This module has the highest inflammation delta in the batch (UC: 0.383, CD: 0.387) and strongest remission reversal, indicating a robust inflammatory activation program. Hub genes include: HEBP2 (heme-binding, oxidative stress/apoptosis), DAP (death-associated protein, autophagy/apoptosis), LRRFIP2 (innate immune signaling, NF-κB activation), PLAUR/uPAR (plasminogen activator receptor, inflammatory migration), ITGAV (integrin αV, inflammatory adhesion/angiogenesis), ZYX and PDLIM4 (focal adhesion/mechanosensing), CCDC88A/GIV (migration scaffold), PARP1 (DNA damage/inflammatory response), LTBP1 (TGF-β latent binding, ECM remodeling), GPR68 (proton-sensing GPCR activated in acidic inflammatory microenvironment), APLN (apelin, inflammatory angiogenesis). The combination of apoptosis, innate immune signaling, adhesion, and migration genes reflects endothelial inflammatory activation with stress response.
Genes
ADI1, APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2, ITGAV, KCNE3, LRRFIP2, LTBP1, PARP1, PDLIM4, PLAUR, PPDPF, PTMS, RAB10, ZCRB1, ZYX
Most correlated modules
- ER-Golgi Trafficking · correlation 0.85
- Respiratory Chain Complex · correlation 0.82
- Mitochondrial Oxidative Stress · correlation 0.82
- p53 Stress Response · correlation 0.76
- Lysosomal Autophagy Program · correlation 0.76
- Complement Innate Immune · correlation 0.76
- Housekeeping Metabolic · correlation 0.75
- Oxidative Phosphorylation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.