LPCAT1 — Lysophosphatidylcholine acyltransferase 1
LPCAT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LPCAT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endocytic Membrane Remodeling migration & adhesion | ARHGAP23, BNIP2, CDK17, EIF4G2, HERC1, KCTD15, LRRC8A, LUZP1 +4 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2 +23 more | |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1 +6 more | View in SCUBA |
| Neutrophils | Inflammasome IL-1 Response Cytokine & chemokine secretion | CSRNP1, EGR3, G0S2, IER3, IFRD1, IL1B, IL1RN, IVNS1ABP +5 more |
About the gene
| Synonyms | AGPAT10, AGPAT9, AYTL2, FLJ12443, LPLAT8 |
|---|---|
| Chromosome | 5: 1456480-1523962 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Exhibits acyltransferase activity. Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero- 3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.