Inflammatory ECM Remodeling
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
The module is dominated by ECM remodeling genes: SULF1 (heparan sulfate remodeling), SERPINE2 (serine protease inhibitor/PAI), FBLN2 (fibulin-2 ECM glycoprotein), ABI3BP (ECM scaffold), ELN (elastin). Additional genes include lipid/eicosanoid mediators (LTC4S, PTGER4), FGF18 (growth factor), and GUCY1A1 (NO/cGMP signaling). The module is significantly upregulated with UC inflammation and downregulated with remission, consistent with inflammatory vascular ECM remodeling. PALLD (cytoskeletal/ECM organization) and CGNL1 (tight junction-associated) further support vascular structural remodeling. Neighbor M128 also features ECM components, reinforcing a structural remodeling neighborhood.
Genes
ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, ELN, FBLN2, FGF18, GUCY1A1, LTC4S, PALLD, PTGER4, SERPINE2, SULF1
Most correlated modules
- Arterial EC Identity · correlation 0.89
- Inflammatory Angiogenesis · correlation 0.78
- YAP Mechanotransduction · correlation 0.73
- Quiescent EC Identity · correlation 0.69
- Vascular Homeostasis · correlation 0.66
- Endothelial Quiescence · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.