TTYH3 — Tweety family member 3
TTYH3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TTYH3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A +7 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, COPB1, EXOC5 +18 more | View in SCUBA |
About the gene
| Synonyms | KIAA1691 |
|---|---|
| Chromosome | 7: 2631961-2664802 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel |
| Biological process | Ion transport, Transport |
Function
Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.