WDFY1 — WD repeat and FYVE domain containing 1
WDFY1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WDFY1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Lipid Metabolism Metabolite transfer | ACSL4, APOL1, CDK2AP2, COPS8, GBE1, GOLM1, MAPRE1, NPC1 +5 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B +22 more | View in SCUBA |
About the gene
| Synonyms | FENS-1, KIAA1435, WDF1, ZFYVE17 |
|---|---|
| Chromosome | 2: 223855716-223945357 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.