Endothelial Membrane Transport
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
AQP1 (aquaporin-1) is a canonical endothelial water channel critical for vascular permeability and is a core endothelial identity gene. RDX (radixin) is an ERM-family protein linking plasma membrane to the actin cytoskeleton, important for endothelial cell polarity and barrier function. SNX3 (sorting nexin 3) mediates endosomal cargo sorting and membrane trafficking. TNK2 (ACK1) is a non-receptor tyrosine kinase regulating actin and endosomal trafficking. OSTF1 drives actin remodeling. SPRY1 (Sprouty1) is a feedback inhibitor of RTK/VEGF signaling in endothelial cells. CLIC5 is a chloride channel enriched in endothelial cells. CDH24 is a cadherin involved in cell-cell adhesion. TBX3 and CEBPG are transcription factors. FAP (fibroblast activation protein) is expressed in activated endothelium/stroma. The module is upregulated in inflammation, consistent with endothelial membrane remodeling and permeability changes. AQP1 + RDX + CLIC5 + SNX3 point to a membrane transport and cytoskeletal organization program.
Genes
AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1, RAVER2, RBPMS, RDX, RUNDC3B, SNX3, SPRY1, TBX3, TNK2, TSPAN13, UBE2J1
Most correlated modules
- Inflammatory Angiogenic Activation · correlation 0.81
- Inflammatory Kinase Signaling · correlation 0.79
- Endothelial Junction Identity · correlation 0.78
- Endocytic Membrane Remodeling · correlation 0.75
- Endothelial Lipid Signaling · correlation 0.74
- Mitophagy Stress Response · correlation 0.70
- Angiogenic Endothelial Identity · correlation 0.69
- Capillary Endothelial Identity · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.