mRNA Splicing & Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
MAGOH, DDX39A, LSM4, and SNRPF are core components of the spliceosome and exon junction complex involved in pre-mRNA splicing and mRNA export. RAB22A and RAB5C are endosomal Rab GTPases involved in vesicular trafficking. ARF1 is a GTPase regulating Golgi vesicle budding. ARL6IP1 participates in ER/Golgi trafficking. TAP2 is involved in peptide transport for MHC class I antigen presentation. MXI1 antagonizes Myc-driven proliferation. TOB1 is an anti-proliferative factor. MRPL54 is a mitochondrial ribosomal protein. The module is moderate coherence combining RNA splicing/mRNA processing with endosomal trafficking, likely reflecting a shared housekeeping co-expression program.
Genes
ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, DDX39A, EIF5A, GALNT3, GPS2, HEXA, KDM7A, LSM4, MAGOH, MGAT4A, MRPL54, MXI1, POLD2, PPBP, PSMD9, RAB22A, RAB5C, SLC10A3, SNRPF, TAP2, TOB1, VPS4A
Most correlated modules
- T-bet Effector Differentiation · correlation 0.78
- Naive T cell quiescence · correlation 0.74
- Anabolic Activation Response · correlation 0.72
- Innate Stress Signaling · correlation 0.71
- snRNP Splicing · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.