Anabolic Activation Response
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 35 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include LDHA (glycolysis), EIF4A1 (cap-dependent translation initiation), CALM2 (calmodulin, broad signaling), NDUFA5 (mitochondrial complex I), SRSF3/SRSF2 (splicing factors), UBE2S (ubiquitin conjugating enzyme), TUBB4B (microtubule), ATF4 (ISR master TF activated by eIF2α phosphorylation), ATP6V1G1/ATP6V0C (v-ATPase subunits), BUD31/SAP18 (spliceosome-associated). The mix of ATF4 (integrated stress response), LDHA (Warburg metabolism), translation factors, and splicing regulators suggests a broad housekeeping/metabolic program co-regulated during T cell activation. ATF4 links this to neighbor M141 (PPP1R15A/GADD34 activates ATF4 via eIF2α). The module likely captures the anabolic/biosynthetic response of activated T cells.
Genes
ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1, DYNLL2, EIF1AX, EIF4A1, EIF4A3, EMD, FTH1, GYPC, H2AX, LDHA, LRRC59, MAP1LC3B, MAPRE1, MIDN, NDUFA5, NPM1, PAIP2, PTBP1, RSL24D1, SAP18, SERP1, SKP1, SRSF2, SRSF3, SUB1, TUBB4B, UBB, UBE2S
Most correlated modules
- Heat Stress Apoptotic · correlation 0.82
- ER Proteotoxic Stress · correlation 0.82
- TCR Early Activation · correlation 0.81
- hnRNP Splicing Complex · correlation 0.80
- snRNP Splicing · correlation 0.77
- Late Activation Autophagy · correlation 0.77
- TGF-beta Response · correlation 0.77
- Chromatin-Splicing Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.