TRIM69 — Tripartite motif containing 69
TRIM69 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIM69's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 more | View in SCUBA |
| Gamma-delta T cells | EOMES Effector Program T cell maturation | AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT +25 more | |
| Monocytes | IRF1 Innate Activation Innate immunity | BAZ1A, CFLAR, FNIP2, IRF1, MARCKS, NABP1, THAP2, ZFYVE16 | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2 +6 more |
About the gene
| Synonyms | RNF36, Trif, TRIMLESS |
|---|---|
| Chromosome | 15: 44728988-44767829 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Apoptosis, Ubl conjugation pathway |
Function
E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.