TCR Inhibitory Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Exhaustion |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
FYN (Src-family kinase, TCR proximal signaling), CBLB (E3 ligase, TCR/CD28 negative regulator linked to anergy/exhaustion), PIK3IP1 (PI3K inhibitor, raises T cell activation threshold), SLA (Src-like adaptor, inhibitory), SOCS1 (suppressor of cytokine signaling), AFF4 (super elongation complex), ISG20 (interferon-stimulated gene), and PPM1B (phosphatase, inactivates stress kinases). The co-occurrence of FYN, CBLB, PIK3IP1, SLA, and SOCS1 — all negative regulators of TCR and cytokine signaling — defines a T cell inhibitory/exhaustion regulatory program. Neighbor context with M40 (TCR threshold) reinforces this interpretation.
Genes
AFF4, CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20, PARP8, PIK3IP1, PPM1B, RNF115, SLA, SMAP2, SOCS1, ST3GAL1, SYTL3, XPO6
Most correlated modules
- mRNA Splicing Regulation · correlation 0.87
- Chromatin Epigenetic Regulation · correlation 0.86
- cAMP Lipid Signaling · correlation 0.86
- Ubiquitin-p53 Regulation · correlation 0.86
- TCR Threshold Regulation · correlation 0.86
- Chromatin Remodeling Signaling · correlation 0.82
- Autophagy Stress Response · correlation 0.82
- Activation Stress Response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.