TRIP11 — Thyroid hormone receptor interactor 11
TRIP11 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIP11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin TF Regulation DNA/chromatin regulation | ALDH9A1, ARMC1, ATIC, ERAP2, HDAC7, KAT8, LTN1, PHF14 +10 more | |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1 +11 more |
About the gene
| Synonyms | CEV14, GMAP-210, GMAP210, Trip230 |
|---|---|
| Chromosome | 14: 91965991-92040896 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.