TCIM — Transcriptional and immune response regulator
TCIM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCIM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1 +8 more | View in SCUBA |
| Fibroblasts | NF-κB Stress Response Inflammatory | EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SAT1, SLC20A1 +3 more | View in SCUBA |
| Goblet cells | Actin Cytoskeletal Remodeling Cytoskeletal | ACTN4, ACTR3, BHLHE40, CAP1, FHL2, KCNK1, LRP10, SDCBP +3 more | View in SCUBA |
| Smooth muscle cells | Telocyte/Fibroblast Contamination Cell contamination | ABI3BP, ADH1B, ASB2, BCHE, BMP4, C5orf66-AS1, CDCA7L, FENDRR +5 more | View in SCUBA |
About the gene
| Synonyms | C8orf4, hTC-1, TC-1, TC1 |
|---|---|
| Chromosome | 8: 40153482-40155310 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.