SLC7A11 — Solute carrier family 7 member 11
SLC7A11 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC7A11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Actin Cytoskeletal Remodeling Cytoskeletal | ACTN4, ACTR3, BHLHE40, CAP1, FHL2, KCNK1, LRP10, SDCBP +3 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | SPP1+ Inflammatory Macrophage Inflammatory | DOCK4, DUSP4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2 +6 more | View in SCUBA |
About the gene
| Synonyms | xCT |
|---|---|
| Chromosome | 4: 138164097-138242349 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Transport |
Function
Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L- cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis. In vitro can also transport L-aspartate. May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.