SPIB — Spi-B transcription factor
SPIB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPIB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | FRC function Immune interaction | ADRA2A, ANKRD29, CCL19, CCL21, CTSH, GP1BA, IL3RA, KCNK13 +3 more | View in SCUBA |
| Goblet cells | Notch Secretory Specification Epithelial development | EDN1, EREG, FKBP1A, GPRC5C, HES4, HES5, MYC, NOTCH2 +4 more | View in SCUBA |
About the gene
| Synonyms | SPI-B |
|---|---|
| Chromosome | 19: 50418938-50431314 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.