ER Protein Processing
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 50 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 17 of 50 genes have a known function matching the annotation |
Why this annotation
The top hub genes and the broader gene list are dominated by ER-resident and secretory pathway components: SELENOF and SELENOT (ER-localized selenoproteins involved in oxidative folding), SPCS2 (signal peptidase complex), REEP5 (ER tubule shaping), ATP6AP1/ATP6AP2/ATP6V0B (vacuolar H+-ATPase accessory and subunit components critical for ER/Golgi pH), OSTC and DAD1 (oligosaccharyltransferase complex, N-glycosylation), EMC7 (ER membrane protein complex), RER1 (ER retrieval), TMCO1 (ER calcium homeostasis), BSG (basigin, membrane glycoprotein). Mild mono_mac enrichment is consistent with monocyte-derived macrophages having active secretory/ER programs. This is a coherent ER membrane and protein processing module.
Genes
ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31, BSG, CAPNS1, CD53, CNBP, COPB2, DAD1, DERL2, EMC7, GABARAPL2, GLRX2, HEXB, M6PR, MESD, MRPL32, OCIAD1, ORMDL2, OSTC, P4HB, PBDC1, PDCD10, PMP22, PSMD6, PTPN6, RABAC1, REEP5, RER1, SDF4, SELENOF, SELENOT, SFT2D1, SLC35B1, SPCS1, SPCS2, TM2D2, TMBIM4, TMCO1, TMED2, TMEM50A, TMEM59, TMEM9B, TOR1A, YIF1A
Most correlated modules
- Actin Cytoskeleton Organization · correlation 0.97
- Proteasome UPS · correlation 0.95
- Protein Biogenesis · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.95
- Glycogen Metabolism · correlation 0.94
- Phagocytic Endolysosomal · correlation 0.94
- RNA Processing & Repair · correlation 0.93
- Glycolytic Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.