SSH1 — Slingshot protein phosphatase 1
SSH1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SSH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST +4 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Endothelial cell development | FAM241A, FAM43A, KLF6, MYC, NFATC1, PHLDA1, PIM3, PLEKHO2 +7 more | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more | |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more | View in SCUBA |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D +23 more | View in SCUBA |
| Monocytes | Endosomal Sorting Vesicular traficking | FPGS, GAB2, GGA2, HGS, MAFG, PIK3R5, SEMA6B, TPRA1 +1 more | View in SCUBA |
| Natural Killer cells | Resident NK program Gut residency | ACP5, CDH17, CHCHD10, CKLF, ID3, KRT81, KRT86, NEDD9 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA1298, SSH1L |
|---|---|
| Chromosome | 12: 108778191-108857590 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Hydrolase, Protein phosphatase |
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.