GPR65 — G protein-coupled receptor 65
GPR65 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR65's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activation/Migration BCR/AP1/NFKb pathway | AHNAK, DUSP10, DUSP8, GGA1, GPR183, IDS, KLF6, LDLRAD4 +11 more | View in SCUBA |
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, IFI44, IFNGR1 +12 more | View in SCUBA |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more | View in SCUBA |
| Macrophages | Glycogen Metabolism Housekeeping | ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more | View in SCUBA |
| Neutrophils | Inflammatory Resolution Stress | ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, JOSD1 +4 more |
About the gene
| Synonyms | hTDAG8, TDAG8 |
|---|---|
| Chromosome | 14: 88005135-88014811 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Apoptosis |
Function
Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 7.4. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR65 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also act as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and regulating T-cell metabolism. Acts as a regulator of inflammation by mediating pH-sensing of extracellular acidification which takes place in inflamed tissues: activation regulates endo-lysosomal function of immune cells and T-cell metabolism (By similarity). Constitutively active in endosomes and stimulates adenylate cyclase production from endosomes independently from extracellular pH changes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.