SAMD1 — Sterile alpha motif domain containing 1
SAMD1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAMD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2 +11 more | View in SCUBA |
About the gene
| Chromosome | 19: 14087851-14091036 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor. Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs. Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell.
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.