SMAD1 — SMAD family member 1

SMAD1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SMAD1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Tfh program B cell help	BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PASK +10 more	View in SCUBA
Endothelial	Venous EC Identity Endothelial cell development	ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more	View in SCUBA
Pericytes	BMP-SMAD Signaling Developmental	CTSH, ETS2, EXOC3L2, IL3RA, ITM2A, MCF2L, NDST1, PDE2A +3 more	View in SCUBA

About the gene

Synonyms	JV4-1, MADH1, MADR1
Chromosome	4: 145481194-145559176
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.