SNRNP40 — Small nuclear ribonucleoprotein U5 subunit 40
SNRNP40 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNRNP40's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CDK4, CENPX, CYC1, FDPS, GGCT, LSM3 +14 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
About the gene
| Synonyms | HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57 |
|---|---|
| Chromosome | 1: 31259568-31296788 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | mRNA processing, mRNA splicing |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.