OTUD1 — OTU deubiquitinase 1
OTUD1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OTUD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18 +11 more | View in SCUBA |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more | View in SCUBA |
| Monocytes | Immediate-Early Inflammatory Inflammatory | CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ +3 more | View in SCUBA |
About the gene
| Synonyms | DUBA7, OTDC1 |
|---|---|
| Chromosome | 10: 23439075-23442377 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | Ubl conjugation pathway |
Function
Deubiquitinating enzyme that specifically hydrolyzes 'Lys- 63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.