NSMCE3 — NSE3 homolog, SMC5-SMC6 complex component
NSMCE3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSMCE3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18 +11 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more | View in SCUBA |
| Gamma-delta T cells | TCR Early Activation TCR Signaling | BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more | |
| Mucosal-associated invariant T cell | mRNA Decay Program RNA processing & translation | ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DUSP2, DYNLL2 +13 more |
About the gene
| Synonyms | HCA4, MAGEG1, MAGEL3, NDNL2, NSE3 |
|---|---|
| Chromosome | 15: 29264989-29269822 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Tumor antigen |
| Biological process | DNA damage, DNA recombination, DNA repair, Growth regulation, Ubl conjugation pathway |
Function
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.