TCR early activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Top hubs are immediate-early/activation transcription factors NR4A3, PER1, FOSL2, ELL2, and TCR-signaling related RALGAPA1, plus KDM6B and CCNT1. This is a TCR activation/AP-1/NR4A early response program, increased with inflammation. CLEC2D and several signaling genes support activation context.
Genes
ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2, JOSD1, KDM6B, NR4A3, NUP98, PAF1, PCNX4, PER1, POLR3E, RALGAPA1, RANBP2, YWHAZ, ZBTB21
Most correlated modules
- Glucocorticoid Immunoregulation · correlation 0.73
- TCR signaling · correlation 0.73
- Immediate early activation · correlation 0.72
- IL6-STAT3 Signaling · correlation 0.55
- Integrated Stress Response · correlation 0.51
- NF-kB activation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.