Effector Immune Activation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are immune signaling/leukocyte genes: SASH3 (lymphocyte adaptor), ABI3, LCP2 (SLP-76, TCR signaling), APBB1IP, CXCR6 (tissue-resident effector T-cell chemokine receptor), CASP4 (inflammatory caspase), SP140, CTSD/LAMP1 (lysosomal), CALCOCO2 (autophagy). Strongly upregulated in inflammation in both UC and CD. This represents an activated/tissue-resident effector T-cell immune program with inflammasome/lysosomal components, not a single canonical pathway. CXCR6 and LCP2 anchor it as effector immune activation.
Genes
ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD, CXCR6, LAMP1, LCP2, SASH3, SKA2, SP140, UBE2D2, YWHAH
Most correlated modules
- RNA & Chromatin Regulation · correlation 0.88
- Integrin Adhesion Migration · correlation 0.86
- Oxidative Phosphorylation · correlation 0.86
- Oxidative phosphorylation · correlation 0.82
- PD-L1 checkpoint · correlation 0.80
- Cytoskeleton & metabolism · correlation 0.78
- Oxidative Phosphorylation · correlation 0.77
- Chromatin regulation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.