PGP — Phosphoglycolate phosphatase
PGP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Nuclear RNA Splicing RNA processing & translation | CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, MAZ, PPIG, PSMD1 +5 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6 +11 more | View in SCUBA |
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD +6 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
About the gene
| Chromosome | 16: 2211593-2214840 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Carbohydrate metabolism |
Function
Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.