PSMD1 — Proteasome 26S subunit, non-ATPase 1
PSMD1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | ARF5, CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3 +17 more | View in SCUBA |
| CD8⁺ T cells | Nuclear RNA Splicing RNA processing & translation | CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, MAZ, PGP, PPIG +5 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16 +10 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 more | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PCSK1N +6 more | View in SCUBA |
About the gene
| Synonyms | P112, Rpn2, S1 |
|---|---|
| Chromosome | 2: 231056845-231173116 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.