UQCC2 — Ubiquinol-cytochrome c reductase complex assembly factor 2
UQCC2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UQCC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3 +9 more | View in SCUBA |
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E +3 more | View in SCUBA |
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more | |
| Innate lymphoid cells | Lipid & Isoprenoid Metabolism Metabolism | ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, LYPLA1, NECAP2, NUBP2 +8 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
| Monocytes | Monocyte Lipid Handling Lysosomal & pahgocytosis | AKR1A1, CD81, FUOM, ISOC2, LAIR1, NPC2, RGL1, SIGLEC1 +1 more | View in SCUBA |
About the gene
| Synonyms | bA6B20.2, C6orf125, Cbp6, M19, MGC14833, MNF1 |
|---|---|
| Chromosome | 6: 33694293-33711727 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.