MEPCE — Methylphosphate capping enzyme
MEPCE belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEPCE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1 +9 more | View in SCUBA |
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more | |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, NDRG1, NUDT4 +9 more | View in SCUBA |
About the gene
| Synonyms | BCDIN3, FLJ20257 |
|---|---|
| Chromosome | 7: 100428322-100434126 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non- enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center. Also required for stability of U6 snRNAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.