Calcium Signal Integration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
CAMK2D (calmodulin-dependent protein kinase II delta) and ITPR2 (inositol 1,4,5-trisphosphate receptor type 2) are both central calcium signaling components. DOCK10 and ELMO1 are Rac GEFs that cooperate in lymphocyte migration and phagocytosis. LRBA regulates CTLA-4 trafficking and immune homeostasis; its deficiency causes immune dysregulation. KMT2C and KAT6A are chromatin modifiers (histone methyltransferase and acetyltransferase). UTRN (utrophin) links cytoskeletal programs to membrane dynamics. TNIK (TRAF2/NCK-interacting kinase) is a Wnt/Rac signaling scaffold. MBNL1 parallels MBNL2 in neighboring module M122, reinforcing RNA splicing co-regulation. The module integrates calcium signaling, Rho/Rac-mediated migration, and chromatin regulation — consistent with a broad T cell activation maintenance or signal integration program.
Genes
ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A, FOXN3, GSK3B, HERC4, ITPR2, KAT6A, KLF12, KMT2C, LRBA, MAML2, MBNL1, PAN3, PIBF1, SKAP1, SNTB1, TBC1D5, TNIK, TXK, UTRN, ZBTB20, ZCCHC7, ZFAND3
Most correlated modules
- Histone Modification · correlation 0.83
- Lymphocyte Survival · correlation 0.82
- STAT4 T cell Identity · correlation 0.80
- Chromatin Epigenetic Regulation · correlation 0.79
- Epigenetic Maintenance · correlation 0.79
- Chromatin Remodeling · correlation 0.78
- TGF-β Immune Regulation · correlation 0.77
- Chromatin Epigenetic Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.