TNFRSF25 — TNF receptor superfamily member 25
TNFRSF25 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF25's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CDC123, CNN2, DGKH, EOGT, FADS3, FYN +7 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Antigen Processing Protein processing & ER | AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2 +8 more |
About the gene
| Synonyms | APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR |
|---|---|
| Chromosome | 1: 6460786-6466175 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.