TIAM1 — TIAM Rac1 associated GEF 1
TIAM1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIAM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
| Endothelial | Quiescent EC Identity Endothelial cell development | ADGRG6, BCAT1, C3orf80, CELF2, CPE, KLF8, KLK10, LYST +5 more | View in SCUBA |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA +13 more |
About the gene
| Chromosome | 21: 31118416-31559977 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.